Unfortunately, I'm only a Gen III and below type of guy, so I'm kinda useless here.

I haven't played White in a while, so the only specific recommendation I have is "get the Larvesta egg once it's available to you, I'm told Volcarona are awesome". ^^;

It's only my opinion, but I think that getting a Ghost type could be a good idea, Chandelure and Golurk seem pretty neat for me, and not only for the Elite 4. Besides, if you want to do a Nuzlocke, a Ghost type will soak up all the Explosion of the world. Other Nuzlockers could think it's a bad idea, but I already saved some of my Pokemons this way with my Misdreavus in my Pearl Nuzlocke.

DID SOMEBODY SAY POKéMON?!

What sort of suggestions do you want? Which starter to pick?

It's generally accepted that Oshawott gives you the easiest run and Snivy the hardest, but it really all comes down to personal preference. Just remember to always have a well-balanced team with good coverage, and you'll be ready for anything! except that final boss god i hate that final boss augh