According to wiki, it's autosomal dominant

Subject: According to wiki, it's autosomal dominant
Author: The Trojanhorse
Posted on: 2009-06-20 10:49:00 UTC

Which if I remember my genetics correctly suggests to me that heterozygotes (people with one copy of the gene) will display the syndrome.

Which means that if one parent is a heterozygote and one parent is a non-sufferer, their children have a fifty fifty chance of having it. If one parent is a homozygote (has two copies of the gene) then all their children will have it.

Wiki seems to have a very comprehensive article on the subject here: http://en.wikipedia.org/wiki/Osteogenesis_imperfecta which should probably all be taken with a pinch of salt, but if you want any biological terms explicated and wiki doesn't have a nice link to a page for them, feel free to PM me on LJ. You have my LJ, right?

Reply Return to messages

Jump to this post's position in the thread ↴

My Introduction? by Maya De'Lune on 2009-06-18 06:49:00 UTC Reply

I believe that this is where I say hello to everyone...I think...I was a mite confused about the process of signing up.
But even if I did it wrong, I shall charge forward.
Hello! I'm Maya. My sister shamelessly plugged this site until I joined, lamenting the wonderful doings of the members. And I decided that it sounded enticing... I do enjoy seeing astray fanfics (and/or Mary sues) burned at the stake. or just corrected.

Welcome! *proffers lembas* (nm) by The Trojanhorse on 2009-06-20 11:47:00 UTC Reply
Hello! by Cinnia Aine on 2009-06-19 03:05:00 UTC Reply

Welcome to the PPC! Here's a special shield from the Raven Armory.
Hello, small mammal. by Maudlin Hart on 2009-06-19 00:23:00 UTC Reply

Welcome to the Board. Please deposit your sanity in the provided receptacle. *provides bucket marked "Warg Fodder"* You shan't be needing it here. Also, have some hugs and The Sword Of Beheading People Just Like In That Movie. Use them wellish.
-Mad Maudlin
Greetings, new person! by Tirya_Moonflame on 2009-06-18 20:45:00 UTC Reply

Have a winged kitten, and watch out for giant glass jars.
Welcome. Here's a tall ship. (nm) by khajidu on 2009-06-18 17:51:00 UTC Reply
greetings by Pads on 2009-06-18 17:04:00 UTC Reply

Have a cup of tea and a flatcap. Handy for, er, disgusing yourself as a grumpy old Yorkshireman. Guaranteed to confuse Sues.
First poke! by Neshomeh on 2009-06-18 16:36:00 UTC Reply

*poke*

Welcome to the Board. The only required reading is the Original Series and the Board Constitution. Everything else is just details.

Entertaining and often useful details, yes, but still just details.

Enjoy. {= )

~Neshomeh
Hello! by Buta on 2009-06-18 16:32:00 UTC Reply

Have a shapeshifting plushie. It can turn into anything, depending on what you want. It can become a flying monkey, and I've seen one turn into a baozi fairy before. And Cthulhu sometimes appears, for those into Nightmare Fuel or cute stuffed eldritch abominations.
First plover! by Tawaki on 2009-06-18 15:43:00 UTC Reply

BTW, will your Agents be based in a TARDIS or a response center?
Hello, my dear. by Seranis on 2009-06-18 14:21:00 UTC Reply

Have some tea leaves and a chainsaw.

The tea leaves are for combat and the chainsaw is for the kitchen.

No, I'm not getting mixed up.

Re: Hello, my dear. by Rosie Azrael on 2009-06-18 18:50:00 UTC Reply

(No, actually, knowing my little sister, you just got that spot on...)

*waves happily* Why hello thar. by Cassie Cameron-Young on 2009-06-18 11:56:00 UTC Reply

Have a bag of pebbles and a Random Shiny Object. Lovely to meet you.
Some Anti-Lustin for the fair lady? (nm) by WikiMaster on 2009-06-18 10:17:00 UTC Reply
Welcome! Have a Capillary Towel and some Convenient Cake! by Sedri on 2009-06-18 09:48:00 UTC Reply

The second is delicious no matter what flavours you like, and the former will clean up most liquid messes, though we haven't tested it on every substance yet. I don't recommend trying.

That said, welcome! KILL THE SUES. *smiles and hands you a little DMS flag*
Welcome! by Sara on 2009-06-18 08:20:00 UTC Reply

Yay for siblings! Here, have an egg whisk. It's shiny, gold-plated, and whisks not only eggs, but spambots and those pesky author wraiths, too. Use it for good and not ~~much~~ evil.

Welcome to the insanity! Enjoy the ride.

Re: Welcome! by Maya De'Lune on 2009-06-18 08:23:00 UTC Reply

I get an egg whisk too? O.O I get a whole spiffy gift basket just for walking in the "door". And since I am VERY much accustomed to insainity, I think I shall enjoy this ride. Thank you =]

Oh, you don't know the half of it. by Sara on 2009-06-18 08:26:00 UTC Reply

*cackles and waits for flying horde of ~~monkeys~~ gift-givers*

Re: Oh, you don't know the half of it. by Maya De'Lune on 2009-06-18 08:28:00 UTC Reply

You know, ever since I was a little girl, I have held a special place in my heart for flying monkeys....-waits and watches the sky with anticipation-

Maya OMG Squee! by Rosie Azrael on 2009-06-18 07:24:00 UTC Reply

*glompattacks the Maya*

Hi dear. Muahahahahaha... what havoc we shall wreak together, eh? Don't forget to check out the other things that others have written... And I'll let someone more senior than I am pull out the Bag O' Links and give you all the necessary information.

For now, I hereby hand you the Poking Stick of Freedom...

*huggles her Maya some more*

Re: Maya OMG Squee! by Maya De'Lune on 2009-06-18 07:40:00 UTC Reply

-huggleglomps Azrael back- I went to FanFiction to survey the damage....it's not pretty. I wanted to cry reading some of the blood and chocolate ones....don't get me started on the Anne rice books.

Re: Maya OMG Squee! by Rosie Azrael on 2009-06-18 07:42:00 UTC Reply

My advice? Go look at the Nix ones... *sobs* And some of the Pierce ones are... Absolutely terrible. Just... Just... *cries*

Re: Maya OMG Squee! by Maya De'Lune on 2009-06-18 08:01:00 UTC Reply

I don't know if I could handle it. what i saw was so ugly....I went back and dared a glance at the Harry potter realm....it will take me years to forget that mess.

Re: Maya OMG Squee! by Rosie Azrael on 2009-06-18 08:29:00 UTC Reply

*hands over some of her precious supply of Bleeprin to the cause of helping to heal her sis's brain* Here. Take two. It's brain bleach plus aspirin. You need it. *huggles* Or would you prefer Bleepka? It's Brain Bleach plus vodka! *brandishes her own egg whisk* We shall slay many author wraiths of Bad Slash this way, yes we shall, Precious!

Re: Maya OMG Squee! by Maya De'Lune on 2009-06-18 08:34:00 UTC Reply

Uugh....Can I have both? I may need it. You work on bad slash? I'm on the wiki site looking up all the terms and categories now. The Lubes were....hilarious. But the Yiff made me a tad queasy...Littlefoot and Cera? really?

Yes. Really. by Tirya_Moonflame on 2009-06-18 21:12:00 UTC Reply

Unfortunately for my opinion of the intelligence of the human race.

The missions can be found at http://agenttrojie.livejournal.com/65922.html#cutid10, which is Trojie and Pads's RC. Good reading if you can handle references to extreme squick.
*hands over both* by Rosie Azrael on 2009-06-18 08:46:00 UTC Reply

Department of Floaters, babe. Anything, any time, any where. And yeah. The LxC is... Just... Yeah. No words. No words AT ALL.

*huggles*

Muahahahahha...

It's better than what by thejadefalcon on 2009-06-18 10:39:00 UTC Reply

Spike and Ducky would be like. O.o

Re: It's better than what by Rosie Azrael on 2009-06-18 22:14:00 UTC Reply

O.o

*downs half a keg of Bleepka to erase that image*

*Casts a Salt Circle to fend it off*

*shudders*

Make it go awaaaaay....

*hides*
AAAAAAARGH! DO NOT WANT! by Cassie Cameron-Young on 2009-06-18 16:15:00 UTC Reply

Dear Eru, I need a Bleeprin scrubbing brush to erase that image from my brain.

And you have just cursed that fic into existence. As if trojie and Pads didn't have enough to do with the threat of more LxC, you just gave those two poor, brave women (well, technically both women) the threat of SxD. Ew ew ew.

Ew.

*goes to drown self in the Fountain of Bleepka*

*cackles* by thejadefalcon on 2009-06-19 13:15:00 UTC Reply

Don't worry. If I'm in the DBS by the time it comes along, I'll volunteer to send my agents in. I'm protective of LBT.

Ditto by The Trojanhorse on 2009-06-20 08:05:00 UTC Reply

Fortunately, though, LittlefootxCera hasn't updated in MONTHS.

*breathes happy, although wary, sigh of relief*

If I was an estabished DBS member... by thejadefalcon on 2009-06-20 10:30:00 UTC Reply

and a new chapter came along, would you be okay to have help?

I'd have to run it by Pads ... by The Trojanhorse on 2009-06-20 10:31:00 UTC Reply

... but theoretically I see no problem - we do a lot of cowrites with third authors and enjoy it :D

I doubt I'll be on for a while though... by thejadefalcon on 2009-06-20 10:39:00 UTC Reply

hit a writer's block for my writing sample, though Pads said my agents are okay.

No hurry :) by The Trojanhorse on 2009-06-20 10:40:00 UTC Reply

Writer's block always loosens after a while. My advice would be to try writing something else instead :) (which would be why I have about twenty unfinished docs in my googledocs that I cycle through...)

The issue is... by thejadefalcon on 2009-06-20 10:42:00 UTC Reply

I have writer's block for basically everything now... except one thing which I may need your help with. Are you familiar with something called Vrolik's syndrome/brittle bone disease/glass-bone syndrome (take your pick of the names)?

I know of it by The Trojanhorse on 2009-06-20 10:43:00 UTC Reply

And could bring myself up to speed with little trouble. Why?

Just a few questions really... by thejadefalcon on 2009-06-20 10:44:00 UTC Reply

The main thing being, is it hereditary after it appears? Will any children (if they can even have children) have it?

According to wiki, it's autosomal dominant by The Trojanhorse on 2009-06-20 10:49:00 UTC Reply

Which if I remember my genetics correctly suggests to me that heterozygotes (people with one copy of the gene) will display the syndrome.

Which means that if one parent is a heterozygote and one parent is a non-sufferer, their children have a fifty fifty chance of having it. If one parent is a homozygote (has two copies of the gene) then all their children will have it.

Wiki seems to have a very comprehensive article on the subject here: http://en.wikipedia.org/wiki/Osteogenesis_imperfecta which should probably all be taken with a pinch of salt, but if you want any biological terms explicated and wiki doesn't have a nice link to a page for them, feel free to PM me on LJ. You have my LJ, right?

Think so... by thejadefalcon on 2009-06-20 10:53:00 UTC Reply

agenttrojie.livejournal.com?

And yeah, I just found that article. Here's the character I'm writing about: http://en.wikipedia.org/wiki/ListofcharactersinMassEffect#Jeff.22Joker.22_Moreau

He's only got Vrolik's syndrome in his legs (and I have no idea if he's hetero or homozygote). In the ME universe, it's possible to treat, but not cure Vrolik's.

Yep that's me :D by The Trojanhorse on 2009-06-20 10:55:00 UTC Reply

Well in that case you've got the luxury of deciding whether it would be better for the plot of your story for him to be a hetero- or homozygote :D

Well, given that I'm plotting... by thejadefalcon on 2009-06-20 10:57:00 UTC Reply

a completely wacko romance story between him and his commanding officer, I'm thinking hetero so that there's a "will any children have it or not" aspect. 'cause angst, why not?

You are talking to the angst *queen* by The Trojanhorse on 2009-06-20 10:57:00 UTC Reply

So I say go the angst!

Yes, Your Majesty... by thejadefalcon on 2009-06-20 10:59:00 UTC Reply

All of my stories barring my Night of the Living Bread parody series have an angst aspect in them at some point. It's kinda annoying sometimes.

:P by The Trojanhorse on 2009-06-20 11:00:00 UTC Reply

It just creeps in, doesn't it.

*nods* by thejadefalcon on 2009-06-20 11:05:00 UTC Reply

Though if it 'creeps' to soap opera levels, I smack it back down with a vengeance. In fact, given that my Pokémon series is growing rapidly darker, I've decided that, to counteract it, every fifty or so chapters, I'll have a completely off the wall chapter. The first one will have far, far, far too many egg jokes because of this guy: http://bulbapedia.bulbagarden.net/wiki/Exeggcute

Ah, crack, the antidote to angst :D (nm) by The Trojanhorse on 2009-06-20 11:06:00 UTC Reply

Unless it's angst-causing crack... by thejadefalcon on 2009-06-20 11:09:00 UTC Reply

I'm not sure which is the worst. The egg puns I'm writing for Chapter Fifty, the Night of the Living Bread parody, that tentacle sex you said I should attempt to write, or my Buffy the Vampire Slayer/Teletubbies crossover.

Can't be any worse than Kirk/Spock research!crack .. (nm) by The Trojanhorse on 2009-06-20 11:10:00 UTC Reply

Research!crack? (nm) by thejadefalcon on 2009-06-20 11:12:00 UTC Reply

Well ... by The Trojanhorse on 2009-06-20 11:13:00 UTC Reply

... Spock has to do things, uh, methodically ...

Look, it's not my fault, I'm a Kirk/Bones girl all the way, but Pads wanted a Kirk/Spock story, and I took it so far and then she took over and it's turned into another one of our cowrites of Doom ...

Am I the only one who thinks... by thejadefalcon on 2009-06-20 11:17:00 UTC Reply

that Kirk should have been castrated for galactic security?

Ha! First welcome by PitViperOfDoom on 2009-06-18 07:19:00 UTC Reply

Hello, hello! Welcome!

http://ppc.wikia.com/wiki/PPC_Wiki will tell you all there is to know about the PPC, and the original series can be found here: http://www.misssandman.com/PPC/story.html

I gift you with a weighted companion cube and a key lime pie.

Re: Ha! First welcome by Maya De'Lune on 2009-06-18 07:35:00 UTC Reply

I get a poking stick, a pie....(god I love pie) and a weighted cube. This is awesome....I'm going to like it here. And Thank you.